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Levitra

Levitra is a fast-acting medication for erectile dysfunction that starts working in as little as 10 minutes. Its active ingredient, vardenafil, increases blood flow to help achieve and maintain an erection. Levitra works well with food, has fewer visual side effects, and is effective for men with diabetes.

A close-up image of a yellow Levitra pill manufactured by Bayer.

Levitra, which is known generically as vardenafil, has been a popular choice among men seeking treatment for erectile dysfunction (ED) ever since it was approved by the U.S. Food and Drug Administration (FDA) [1] and the European Medicines Agency (EMA) [2] in 2003. Designed to help men achieve and maintain an erection sufficient for sexual activity, Levitra has provided a reliable solution for millions of people worldwide who are affected by this condition, which impacts both physical and emotional well-being.

Developed by Bayer HealthCare AG in collaboration with GlaxoSmithKline, Levitra was introduced following the success of Viagra, the first oral ED treatment. Its introduction marked a significant step in expanding treatment options for men, offering a different profile in terms of onset and duration. Approved in numerous countries and available in both brand-name and generic forms, Levitra remains a cornerstone of ED treatment, backed by years of clinical research and real-world use.

In terms of market presence, vardenafil occupies a significant position in the global ED drug market. As of 2023, Europe accounted for around 30% of the global vardenafil market, with countries such as Germany, the United Kingdom and France contributing substantially thanks to their well-established healthcare systems and high healthcare spending [3,4].

What is Levitra?

Levitra is a pharmaceutical medication containing the active ingredient vardenafil, which is used to treat ED in men. As a phosphodiesterase type 5 (PDE5) inhibitor [5], it works by relaxing the smooth muscles in the blood vessels and enhancing blood flow to the penis, facilitating an erection during sexual stimulation. Unlike some other erection medication, Levitra is noted for its relatively rapid onset, becoming effective within 10 to 60 minutes, and remaining effective for up to five hours. It is known for its reliability and is often preferred due to its fast onset, effectiveness even after meals, and lower risk of certain side effects like visual disturbances.

Levitra is marketed by Bayer AG, but generic versions containing the same active ingredient (vardenafil), are also widely available. These generics contain the same active ingredient and meet rigorous regulatory standards for safety and efficacy, offering a more affordable alternative to the branded drug. By addressing the physiological barriers to achieving an erection, Levitra offers a targeted solution for men seeking to improve their sexual potency.

How effective is it?

Levitra has proven to be a highly effective treatment for erectile disorder, with clinical trials demonstrating significant improvements in achieving and maintaining erections. In a multicentre study published in Mayo Clinic Proceedings in 2005, approximately 80% of men with ED who took vardenafil (Levitra's active ingredient) at 10 mg dose reported successful intercourse, compared to 32% in the placebo group [6]. Success rates were notably higher in men with mild to moderate ED, though those with severe cases also experienced benefits.

Users typically report increased confidence and satisfaction, with the effects kicking in as early as 10–15 minutes after ingestion [7], although 30–60 minutes is more common. The effects of Levitra last for about 4–5 hours, providing a reliable window for sexual activity. Real-world studies, such as a 2004 analysis in the journal European Urology, confirm these findings, with over 90% of users reporting consistent improvements when the drug is taken as prescribed [8]. However, effectiveness can vary based on individual causes of ED such as diabetes or cardiovascular conditions, which is why it is important to consult a doctor.

The benefits of Levitra

Levitra offers several distinct advantages for men fighting ED, as supported by clinical research and patient-reported outcomes. Its unique profile makes it a compelling choice for many, particularly those seeking a balance of rapid onset and manageable duration. The key benefits of Levitra are summarised below.

  • Rapid onset: Levitra typically takes effect within 15–30 minutes, with some studies noting efficacy as early as 10 minutes in certain patients [7]. This allows for spontaneity in sexual activity.
  • Effective across ED severities: Clinical trials show that Levitra improves erections in 71–80% of men, including those with mild, moderate or severe ED, making it a versatile treatment for various patient needs [9].
  • Fewer side effects: Some users report fewer visual disturbances compared to Viagra, which is known to cause blue-tinged vision [10].
  • Moderate duration: With effects lasting four to five hours, Levitra provides a sufficient window for sexual activity, offering a more convenient option than some alternatives with a prolonged duration.
  • Lifestyle flexibility: Levitra can be taken with or without food, though high-fat meals may slightly delay the onset of effects. This flexibility suits varied lifestyles and reduces the need for advance planning.
  • High Patient Satisfaction: Studies report that men using Levitra experience improved confidence and relationship satisfaction. In fact, more than 70% of users have noted consistent success in real-world settings [9].
  • Favourable for Specific Conditions: Levitra has demonstrated particular efficacy in treating ED in men with diabetes or following prostatectomy, where other treatments may be less effective [11].

These benefits, supported by robust clinical data, emphasise Levitra’s position as a dependable and versatile ED treatment. Men considering Levitra should discuss its suitability with their doctor to ensure it aligns with their health and lifestyle needs.

Who can benefit from Levitra?

Levitra is designed to help men with impotence, a condition that affects an estimated 30 million men in the US alone. ED can stem from physical, psychological or mixed causes, and Levitra’s efficacy makes it suitable for a broad range of individuals, provided they have been evaluated by a doctor. The primary groups who may benefit from Levitra are listed below:

  1. Men with physical causes of ED: Levitra is effective for those with ED linked to conditions such as diabetes, which affects up to 50% of men with the disease, or hypertension, which is a factor in 30% of ED cases. It also helps men with vascular issues by enhancing blood flow to the penis.
  2. Men with psychological or mixed causes: Stress, anxiety or depression can contribute to ED in around 20% of cases. Levitra can help men with performance anxiety or mixed physical and psychological ED by providing reliable erections, which may reduce psychological barriers over time.
  3. Older men experiencing age-related ED: The prevalence of ED rises with age, affecting 40% of men over 40 and 70% of those over 70. Levitra’s rapid onset and effectiveness make it a practical choice for older adults, although those with heart conditions or who are taking nitrates require careful medical supervision.
  4. Men seeking a shorter-acting option: For those who prefer a medication that works quickly and leaves the system within 4–5 hours, Levitra is well suited to planned sexual activity as it minimises prolonged effects compared to longer-acting alternatives.

While Levitra is suitable for many, it’s not a one-size-fits-all solution. Men with underlying health issues, such as severe heart disease or low blood pressure, or those taking certain medications like nitrates, should consult a doctor to ensure it is safe for them to take Levitra. A healthcare provider can assess whether Levitra is suitable for an individual, particularly those with complex medical histories.

Potential risks and side effects

Like all medications, Levitra carries potential risks and side effects, though most are mild and manageable for the majority of users with erection problems [12]. Clinical studies provide clear data on their prevalence, helping men to make informed decisions with their doctors. The common and rare side effects associated with Levitra are listed below, along with guidance on when to seek medical attention.

Common side effects:

  • Headache: Reported by about 15% of users, typically mild and short-lived.
  • Flushing: Affects roughly 10% of users and causes temporary facial redness or warmth.
  • Nasal congestion: Occurs in around 9% of users and is often described as a stuffy nose.
  • Indigestion: Noted by 4–7% of users, it is usually mild and can be alleviated by taking the medication with food.
  • Dizziness: Experienced by around 2% of people, particularly at higher doses.

Rare but serious side effects:

  • Priapism: An erection lasting more than four hours, affecting less than 0.1% of users. This is a medical emergency requiring immediate attention to prevent tissue damage.
  • Sudden vision or hearing loss: This condition is extremely rare (applying to less than 0.01% of users), but any sudden changes in vision or hearing warrant urgent medical care.
  • Severe allergic reactions: Symptoms such as rash, swelling or breathing difficulties are uncommon, but require immediate attention.

Most side effects are transient and diminish as the body adjusts to the medication. Levitra should not be used by men taking nitrates (e.g. for chest pain) or by those with severe heart conditions, as it can cause a dangerous drop in blood pressure. Men experiencing side effects that persist or worsen should consult their doctor, who, based on a medical diagnosis, may adjust the dose or recommend alternatives. Open discussion with a healthcare provider ensures that Levitra is used safely and effectively.

Cost and accessibility

In the European Union, Levitra and its generic version, vardenafil, are accessible therapeutic options for ED, with costs varying by country, dosage, and whether the brand-name or generic version is chosen. The European Commission granted marketing authorisation for Levitra across the EU in 2003, and generic vardenafil drugs such as Valif or Valif Oral Jelly became available after its patent expired, which significantly lowered prices.

In the UK, for example, a single 20 mg vardenafil tablet typically costs between £2.50 and £5.00 (approximately €3.00 and €6.00) through regulated online pharmacies. Prices per tablet decrease for larger quantities. In Germany, the price of generic vardenafil (10 mg) ranges from €5.00 to €10.00 per tablet at local pharmacies, though bulk purchases can reduce the cost to as little as €2.50 per tablet. Across the EU, online pharmacies generally offer prices that are 25–50% lower than those of traditional outlets, with some selling vardenafil for as little as €1.50 per 20 mg tablet when purchased in larger quantities.

Levitra is available on prescription from physical pharmacies and via regulated online platforms throughout the EU. Next-day delivery is available for orders placed before the specified cut-off time. Many EU countries, including the UK and Germany, require an online consultation to ensure suitability, which makes it more accessible for men who are reluctant to visit a doctor in person. Generic vardenafil is widely available, usually via online pharmacies, and is often half the price of discontinued brand-name Levitra. It meets the same EU regulatory standards for safety and efficacy.

Generic Levitra

Generic Levitra, known as vardenafil, offers an affordable alternative to the branded medication originally developed by Bayer HealthCare. Following the expiration of Levitra’s patent in the European Union in October 2018, generic vardenafil became widely available across EU countries, meeting the stringent regulatory standards set by the European Medicines Agency (EMA) for safety, efficacy, and quality. The generic version contains the same active ingredient (vardenafil hydrochloride) and dosages (5 mg, 10 mg and 20 mg) as the branded drug, ensuring comparable performance in treating ED. Clinical studies confirm that generic vardenafil achieves the same success rates as the branded version: 69–81% of men report improved erections [13].

The primary advantage of generic vardenafil is its cost. In the EU, it is often priced at €1.50–€6.00 per 20 mg tablet, compared to brand-name Levitra, which could cost significantly more before its discontinuation. This affordability makes treatment more accessible, particularly for those without insurance coverage or in countries with limited subsidies for ED medications. Generic vardenafil provides the same rapid onset (15–60 minutes) and duration (four to five hours) as the original. Men interested in saving money should discuss generic erection pills with their doctor or pharmacist, who can confirm their suitability.

Levitra vs. other ED treatments

Levitra is PDE5 inhibitor used to treat ED, alongside other potency remedies such as Viagra, Cialis and Spedra. Each medication has its own unique characteristics, so the best choice depends on individual needs, lifestyle and medical advice. The table below compares Levitra with other PDE5 inhibitors, highlighting key differences based on clinical data and patient experience.

Levitra vs. Viagra

Both Levitra and Viagra (sildenafil) take effect within 30–60 minutes and last 4–5 hours. However, Levitra may have a slightly faster onset, taking effect in some users within 15–30 minutes. Levitra is less affected by food intake, whereas the efficacy of Viagra can be delayed by high-fat meals. Success rates are similar, with 65–80% of men reporting improved erections with both medications. Levitra may cause fewer visual side effects than Viagra, which has been linked to rare cases of blue-tinted vision.

Levitra vs. Cialis

Cialis (tadalafil) stands out for its long duration of up to 36 hours, earning it the nickname 'the weekend pill', whereas the effects of Levitra last 4–5 hours. This makes Cialis ideal for men who want the flexibility to take it without having to time doses closely, whereas Levitra suits those who prefer a shorter-acting option. Levitra's onset (15–60 minutes) is faster than Cialis's (30–120 minutes). Both are effective, but Cialis may be preferred for daily low-dose use in men with frequent sexual activity.

Levitra vs. Spedra

Spedra (avanafil) is the fastest-acting PDE5 inhibitor, often taking effect within 15–30 minutes, which matches or surpasses Levitra's onset. However, Levitra’s duration (four to five hours) is slightly longer than Spedra’s (three to five hours). Both have similar efficacy rates (70–80%), but Spedra may cause fewer side effects, such as headaches or flushing, in some users. Levitra's broader real-world use provides more long-term data.

Each medication has its own strengths. Levitra has a rapid onset and is flexible regarding food, Viagra has an established track record, Cialis has an extended duration and Spedra is fast-acting. Factors such as onset time, duration, side effect profile and cost should inform decisions. It is crucial to consult a doctor to ensure the treatment is matched to health conditions, medications, and lifestyle preferences.

Key takeaways

Levitra is a reliable and effective vardenafil-based ED medicine, with a rapid onset and flexible dosing. It has been proven successful in almost 80% of users. Its ability to work within 15–60 minutes and last four to five hours makes it well suited to those seeking a shorter-acting treatment that fits varied lifestyles. With affordable generic vardenafil available across the EU at low prices, access to this treatment has never been easier.

References

  1. U.S. Food and Drug Administration (Apr 2002), "Drug Approval Package: Levitra (Vardenafil Hydrochloride) Tablets", accessdata.fda.gov
  2. European Medicines Agency (Jan 2025), "Summary of the European public assessment report (EPAR) for Levitra", ema.europa.eu
  3. Dataintelo Consulting (Feb 2021), "Vardenafil Market Report | Global Forecast From 2025 To 2033", dataintelo.com
  4. Grand View Research (2024), "France Erectile Dysfunction Drugs Market Size & Outlook", grandviewresearch.com
  5. Wikipedia (2024), "PDE5 inhibitor", wikipedia.org
  6. L Valiquette, J M Young, I Moncada, H Porst, J-G Vézina, B-N Stancil, K Edmunds, F Montorsi (Oct 2005), "Sustained Efficacy and Safety of Vardenafil for Treatment of Erectile Dysfunction: A Randomized, Double-Blind, Placebo-Controlled Study", Mayo Clinic Proceedings, mayoclinicproceedings.org
  7. J D Evans, S R Hill (Aug 2015), "A comparison of the available phosphodiesterase-5 inhibitors in the treatment of erectile dysfunction: a focus on avanafil", Patient preference and adherence, dovepress.com
  8. A-J Potempa, E Ulbrich, I Bernard, M Beneke (Jul 2004), "Efficacy of Vardenafil in Men with Erectile Dysfunction: A Flexible-Dose Community Practice Study", European Urology, europeanurology.com
  9. W J G Hellstrom, M Gittelman, G Karlin, T Segerson, M Thibonnier, T Taylor, H Padma-Nathan (Jan 2013), "Vardenafil for Treatment of Men With Erectile Dysfunction: Efficacy and Safety in a Randomized, Double-Blind, Placebo-Controlled Trial", Journal of Andrology, onlinelibrary.wiley.com
  10. G Roessler, M Vobig, P Walter, B AE Mazinani (Dec 2018), "Ocular side effects of Levitra® (vardenafil) – results of a double-blind crossover study in healthy male subjects", Drug Design, Development and Therapy, dovepress.com
  11. I Goldstein, J M Young, J Fischer, K Bangerter, T Segerson, T Taylor (Mar 2003), "Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study", Diabetes Care, diabetesjournals.org
  12. G M Keating, L J Scott (Sep 2012), "Vardenafil: A review of its use in erectile dysfunction", Drugs, link.springer.com
  13. H Porst, I D Sharlip, D Hatzichristou, E Rubio-Aurioles, M Gittelman, B N Stancil, P M Smith, H J Wilkins, P Pommerville; Vardenafil Study Group (Jun 2006), "Extended duration of efficacy of vardenafil when taken 8 hours before intercourse: a randomized, double-blind, placebo-controlled study", European Urology, sciencedirect.com
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