Vardeforce 20mg tablets 20mg contain vardenafil, a phosphodiesterase type 5 inhibitor that helps men with erectile dysfunction (impotence), to achieve and maintain an erection, when sexually aroused.
Vardeforce 20mg are used to treat erectile dysfunction (impotence) in men, which is inability to achieve or maintain a hard erect penis suitable for sexual activity, due to insufficient blood flow into the penis. Vardeforce 20mg relax the blood vessels in the penis increasing blood flow and causing an erection, which is the natural response to sexual stimulation. However, Vardeforce 20mg will only work if you are sexually aroused.
Vardeforce 20mg contain vardenafil which acts on the erectile tissue of the penis to increase blood flow to cause an erection. During sexual stimulation nitric oxide is released in the erectile tissue of the penis which activates the enzyme guanylate cyclase. This enzyme increases levels of a chemical called cyclic guanosine monophosphate (cGMP), which relaxes the blood vessels in the penis and allows blood to fill the spongy erectile tissues to cause an erection. Another enzyme called phosphodiesterase type 5 (PDE5) breaks down cGMP preventing blood flow into the penis, which causes loss of an erection. Vardeforce 20mg inhibit the action of PDE5 which resolves erectile dysfunction by allowing the natural process of sexual stimulation to activate the cGMP mechanism for achieving and maintaining an erection.
Vardeforce 20mg should be taken within an hour of planned sex and in most cases it helps you to get an erection in about 30 minutes that will last for around 4 hours, provided you are sexually aroused. Vardeforce 20mg do not work if you are not aroused.
Vardeforce 20mg contain the active ingredient vardenafil, which resolves erectile dysfunction (impotence) in men, by increasing blood flow into the penis.
Vardeforce 20mg contain vardenafil, a phosphodiesterase type 5 (PDE5) inhibitor that is used to treat erectile dysfunction in men (impotence). During sexual stimulation nitric oxide is released in the erectile tissue of the penis (corpus cavernosum), and activates the enzyme guanylate cyclase. This increases levels of a chemical called cyclic guanosine monophosphate (cGMP) that relaxes the blood vessels in the penis and allows blood to fill the spongy erectile tissues to cause an erection. Another enzyme called phosphodiesterase type 5 (PDE5) breaks down cGMP preventing blood flow into the penis, which causes loss of an erection. When taken before planned sexual activity, Vardeforce 20mg inhibit the PDE5 allowing cGMP to continue to increase blood flow into the penis causing an erection.
The most commonly reported side effects when taking Vardeforce 20mg include, headache, dizziness or light-headedness, flushing, nasal congestion, dyspepsia (heartburn), nausea. Less common side effects include, visual disturbance, increased tear formation causing watery eyes, changes in blood pressure (hypo and hypertension), sleepiness, dyspnoea (shortness of breath), pain (in the back joints, abdomen).
You should not use Vardeforce 20mg if you:
Several medications interact with Vardeforce 20mg and should either not be taken while you are taking Vardeforce 20mg or only after discussion and instruction from your doctor:
Drugs that cause a serious reaction with Valif: any nitrate medication, such as nitroglycerin for angina, alpha-blockers like terazosin or doxazosin for benign prostatic hyperplasia, verapamil or diltiazem (for high blood pressure)
Drugs that affect Vardeforce 20mg: cimetidine for treating ulcers, antibiotics like erythromycin and rifampicin, itraconazole or ketaconazole (for fungal infections), ritonavir or indinavir (for HIV)
Drugs that are affected by Valif: like doxazosin for benign prostatic hyperplasia
You should take one Vardeforce 20mg with a glass of water approximately 25-60 minutes before sexual activity with or without food. The effect of Vardeforce 20mg can last as long as 4-5 hours after taking your tablet. You should take no more than one tablet a day and only if you plan to have sex.
You should only take a Vardeforce 20mg when you plan to have sex; it is not intended as a regular medication.
You should keep your Vardeforce 20mg in their blister pack until used and store in a cool, dry place where the temperature stays below 30°C.
Vardeforce Tablets contain Vardenafil 20mg, a phosphodiesterase type 5 inhibitor that helps men with erectile dysfunction (impotence) to achieve and maintain an erection, when sexually aroused.
Vardeforce (Vardenafil) is used to treat erectile dysfunction (impotence) in men, which is inability to achieve or maintain a hard erect penis suitable for sexual activity, due to insufficient blood flow into the penis. Vardeforce (Vardenafil) relaxes the blood vessels in the penis, increasing blood flow and causing an erection, which is the natural response to sexual stimulation.
Vardeforce (Vardenafil) is not an aphrodisiac and stimulation will be required to develop an erection.
Vardeforce (Vardenafil) is manufactured clinically by Zenith Pharma.
Erectile dysfunction is also called impotence. Both names mean the inability to attain an erection. There are several different causes of impotence. The most common is the narrowing of the arteries. These unpleasant problems can occur in both young and old men.
To get the best from your treatment, please read the following carefully:
The recommended dose of Vardeforce 20 mg is 10 mg taken as needed approximately 25 to 60 minutes before sexual activity. Based on efficacy and tolerability the dose may be increased to 20 mg or decreased to 5 mg. The maximum recommended dose is 20 mg. The maximum recommended dosing frequency is once per day. Vardeforce 20 mg can be taken with or without food. The mean terminal half-life of vardenafil in patients receiving Vardeforce 20 mg orodispersible tablets ranged between 4 – 6 hours. The onset of activity may be delayed if taken with a high fat meal. Always take this medicine with a large glass of water.
You should only take a Vardeforce 20 mg when you plan to have sex – it is not intended as a regular medication.
When vardenafil film-coated tablets are taken with a high fat meal (containing 57% fat), the rate of absorption is reduced, with an increase in the median tmax of 1 hour and a mean reduction in Cmax of 20%. Vardenafil AUC is not affected. After a meal containing 30% fat, the rate and extent of absorption of vardenafil (tmax, Cmax and AUC) are unchanged compared to administration under fasting conditions.
Vardeforce 20 mg can lower blood pressure, and combining it with alcohol (ethanol) may further increase this effect. You may be more likely to experience symptoms such as dizziness, lightheadedness, fainting, flushing, headache, and heart palpitations. You should avoid or limit the use of alcohol while being treated with Vardeforce 20 mg, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Grapefruit juice may increase the blood levels and effects of certain medications such as Vardeforce 20 mg. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with Vardeforce 20 mg. However, if you have been regularly consuming grapefruit or grapefruit juice with Vardeforce 20 mg, do not alter the amounts of these products in your diet without first talking to your doctor or other healthcare professional. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.
Along with its needed effects, Vardeforce 20 mg may cause some unwanted effects.
Although not all of these side effects may occur, if they do occur they may need medical attention.
Commonly reported side effects of Vardeforce 20 mg include: headache, flushing and nausea. See below for a comprehensive list of adverse effects.
These common side effects are connected to dehydration and usually diminish by increasing water intake.
The following side effects of Vardeforce 20 mg may occur that usually do not need medical attention. These side effects are not dangerous and may normally diminish as your body adjusts to the medicine. Patients presenting with these side effects generally do not need to stop taking Vardeforce 20 mg.
Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Although serious side effects are rare, if you experience any the following serious side effects, stop taking Vardeforce 20 mg and seek emergency medical care immediately.
Vardeforce 20 mg is not suitable for everyone.
Patients should NOT take Vardeforce 20 mg:
Prior to initiating any treatment for erectile dysfunction, it be should considered the cardiovascular status of the patient, since there is a degree of cardiac risk associated with sexual activity. Vardenafil has vasodilator properties, resulting in mild and transient decreases in blood pressure. Patients with left ventricular outflow obstruction, e.g., aortic stenosis and idiopathic hypertrophic subaortic stenosis, can be sensitive to the action of vasodilators including Type 5 phosphodiesterase inhibitors.
Serious cardiovascular events including:
Cerebrovascular disorders (including transient ischaemic attack and cerebral haemorrhage), have been reported in temporal association with vardenafil. Most of the patients in whom these events have been reported had pre-existing cardiovascular risk factors. However, it is not possible to definitively determine whether these events are related directly to these risk factors, to vardenafil, to sexual activity, or to a combination of these or other factors.
Medicinal products for the treatment of erectile dysfunction should be used with caution in patients with:
The concomitant use of alpha-blockers and vardenafil may lead to symptomatic hypotension in some patients because both are vasodilators. Concomitant treatment with vardenafil should only be initiated if the patient has been stabilised on his alpha-blocker therapy.
Concomitant use of vardenafil with potent CYP3A4 inhibitors such as itraconazole and ketoconazole (oral form) should be avoided as very high plasma concentrations of vardenafil are reached if the medicinal products are combined. Vardenafil dose adjustment might be necessary if moderate CYP3A4 inhibitors such as erythromycin and clarithromycin, are given concomitantly.
Concomitant intake of grapefruit or grapefruit juice is expected to increase the plasma concentrations of vardenafil. The combination should be avoided.
The co-administration of vardenafil with nitrates or nitric oxide donors (such as amyl nitrite) in any form is contraindicated.
Vardeforce 20 mg is contraindicated in patients who have loss of vision in one eye because of non-arteritic anterior ischemic optic neuropathy (NAION), regardless of whether this episode was in connection or not with previous phosphodiesterase 5 (PDE5) inhibitor exposure.
Medicinal products for the treatment of erectile dysfunction should generally not be used in men for whom sexual activity is inadvisable (e.g. patients with severe cardiovascular disorders such as unstable angina or severe cardiac failure.
The safety of vardenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated until further information is available:
Some medicines may cause problems, especially these:
Don't drink grapefruit juice when you use Vardeforce 20 mg. It can interfere with the usual effect of the medicine. Alcoholic drink can make erection difficulties worse.
Vardenafil is an oral therapy for the improvement of erectile function in men with erectile dysfunction.
In the natural setting, i.e. with sexual stimulation, it restores impaired erectile function by increasing blood flow to the penis.
Penile erection is a haemodynamic process. During sexual stimulation, nitric oxide is released. It activates the enzyme guanylate cyclase, resulting in an increased level of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. This in turn results in smooth muscle relaxation, allowing increased inflow of blood into the penis.The level of cGMP is regulated by the rate of synthesis via guanylate cyclase and by the rate of degradation via cGMP hydrolysing phosphodiesterases (PDEs).
Vardenafil is a potent and selective inhibitor of the cGMP specific phosphodiesterase type 5 (PDE5), the most prominent PDE in the human corpus cavernosum. Vardenafil potently enhances the effect of endogenous nitric oxide in the corpus cavernosum by inhibiting PDE5. When nitric oxide is released in response to sexual stimulation, inhibition of PDE5 by vardenafil results in increased corpus cavernosum levels of cGMP. Sexual stimulation is therefore required for vardenafil to produce its beneficial therapeutic effects.
Do not take more than one dose of Vardeforce 20 mg per day.
It is recommended that tablets be taken with at least one full glass of water.
Do not consume grapefruit or grapefruit products while taking Vardeforce 20 mg.
Always talk to your doctor before taking ANY medication for erectile dysfunction. Some erectile dysfunction medications are not suitable for men with certain medical conditions, and your doctor can advise you on an alternative.
Call your doctor immediately if you experience dizziness or feel nauseous during sexual activity, or develop pain, numbness, tingling in your chest, arms, neck, or jaw.
Seek emergency treatment if an erection lasts more than 4 hours.
Do not take Vardeforce 20 mg if you are also taking a nitrate drug (such as nitroglycerin or isosorbide dinitrate/mononitrate) for chest pain or heart problems. Do not take Vardeforce 20 mg with recreational drugs such as "poppers". Taking these substances together can cause a sudden and dangerous drop in blood pressure.
Always buy your medications from a reputable supplier as there are a lot of counterfeit products on the market.
Certain lifestyle and psychological factors, such as smoking, drinking, and stress, can impact on erectile dysfunction. Eliminating these may also help improve the erection, for example:
Never take other erectile dysfunction medications at the same time as taking Vardeforce 20 mg.
Seek urgent medical advice if an allergic reaction, sudden vision loss or painful erections lasting more than four hours occur.
Drinking alcohol after taking Vardeforce 20 mg may lower blood pressure and decrease sexual performance.
