Understanding Cialis: How it works

Cialis, known generically as tadalafil, is a drug used primarily to treat erectile dysfunction (ED) and symptoms of benign prostatic hyperplasia (BPH). Developed by the pharmaceutical company Eli Lilly and Co, Cialis has revolutionised the treatment of ED since its approval by the US Food and Drug Administration (FDA) in 2003.

Cialis' journey began in the 1990s, when researchers at ICOS Corporation were investigating compounds to treat cardiovascular disease. During clinical trials, they discovered that one of these compounds, tadalafil, showed promising effects in relaxing penile muscles and increasing blood flow to the penis, leading to erections. Recognising its potential, ICOS partnered with Eli Lilly and Co. to develop tadalafil as a treatment for ED. After rigorous testing, Cialis received FDA approval, marking a significant advancement in ED therapy.

How does Cialis work?

Cialis belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. It works by inhibiting the enzyme PDE5, which is responsible for breaking down cyclic guanosine monophosphate (cGMP), a chemical that promotes smooth muscle relaxation and increased blood flow to the penis. By blocking PDE5, Cialis prolongs the action of cGMP, allowing erections to last longer during sexual stimulation.

Effects based on different amounts of tadalafil

100 mg: This is not a standard dose of Cialis. The maximum recommended dose is usually 20 mg. Taking too much tadalafil may increase the risk of side effects without providing any additional benefit.

50 mg: Again, 50 mg is not a standard dose for Cialis. It's important to follow the recommended dosage to ensure safety and effectiveness.

40 mg, 20 mg, 10 mg: These are standard doses used to treat ED. Effects typically last up to 36 hours, earning Cialis the nickname “the weekend pill”. The lower doses are typically sufficient for most men, while higher doses may be appropriate for those with more severe ED or who don't respond adequately to lower doses.

5 mg: This lower dose is often used to treat both BPH and ED. It may be suitable for men who need daily treatment or who experience side effects with higher doses.

Main advantages of Cialis

✔ Long-lasting effects: Cialis offers the advantage of a longer duration of action compared to other ED medications, allowing for greater spontaneity in sexual activity.

✔ Flexible dosage: With different strengths available, Cialis can be tailored to individual needs and preferences, providing options for both on-demand and daily use.

✔ Efficacy: Clinical studies have demonstrated the effectiveness of Cialis in improving erectile function and overall sexual satisfaction in men with ED.

✔ Safety profile: When used as directed, Cialis is generally well tolerated with few serious side effects reported.

✔ Treatment of BPH: In addition to ED, Cialis is approved for the treatment of BPH symptoms by providing relief of urinary symptoms such as frequent urination and difficulty starting a stream of urine.

Dosing recommendations

For ED: The recommended starting dose is usually 10 mg, taken before sexual activity as needed. Depending on individual response and tolerability, the dose may be increased to 20 mg or decreased to 5 mg.

For BPH: A daily dose of 5 mg is often appropriate to relieve urinary symptoms associated with BPH. This lower dose provides continuous improvement over time.

Generic Cialis

Recently, generic Cialis has become available as a more affordable alternative to the brand name medication. These generics contain the same active ingredient, Tadalafil, and are made to the same quality and safety standards as the brand name product. While they may vary in appearance and price, generic Cialis is a cost-effective option for those seeking treatment for ED or BPH.

In summary, Cialis (tadalafil) is a breakthrough medicine in the treatment of erectile dysfunction and benign prostatic hyperplasia. With its extended duration of action, flexible dosing options and proven efficacy, Cialis has improved the quality of life for countless men around the world, giving them hope and confidence when it comes to intimacy and sexual health.